Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: A prospective study

• Published in: Journal of medical virology Vol. 70; no. 3; pp. 350 - 354
• Main Authors: Nakayoshi, Tomokuni, Maeshiro, Tatsuji, Nakayoshi, Tomofumi, Nakasone, Hiroki, Sakugawa, Hiroshi, Kinjo, Fukunori, Orito, Etsuro, Mizokami, Masashi
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2003; Wiley-Liss
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Carcinoma, Hepatocellular - etiology; chronic hepatitis B; Disease Progression; Female; Genotype; genotypes; hepatitis B e antigen; Hepatitis B e Antigens - blood; Hepatitis B virus - genetics; Hepatitis B virus - pathogenicity; Hepatitis B, Chronic - blood; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - virology; Human viral diseases; Humans; Infectious diseases; Japan; liver cirrhosis; Liver Cirrhosis - etiology; Liver Neoplasms - etiology; Male; Medical sciences; Middle Aged; Prospective Studies; Viral diseases; Viral hepatitis; Japan; Human; Prognosis; Orthohepadnavirus; Hepatic disease; Genotype; Infection; Virus; Viral hepatitis B; Hepadnaviridae; Viral disease; Digestive diseases; Hepatitis B virus; Comparative study
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.10270

The factors contributing to the prognosis of hepatitis B virus (HBV)‐ related chronic liver disease were assessed prospectively in 72 patients with chronic hepatitis B confirmed clinically and pathologically. A comparative study was undertaken between patients infected with genotype B and those with genotype C. During the follow‐up period, 13 (81.3%) of 16 patients with genotype B who were initially hepatitis B e antigen (HBeAg) positive became HBeAg negative and 14 (51.9%) of 27 with genotype C became HBeAg negative. HBeAg had been cleared in 8 (61.5%) of 13 patients with genotype B within the first 2 years of the follow‐up, but in only one (7.1%) of 14 with genotype C (P < 0.05). Four (11.4%) of 35 patients with genotype B had progressed to cirrhosis, whereas, 12 (32.4%) of 37 patients with genotype C progressed to cirrhosis, including two patients with hepatocellular carcinoma. Multivariate analysis showed that difference in HBV genotype influenced significantly either the clearance of HBeAg or the development of cirrhosis. In conclusion, HBeAg was cleared from sera more frequently and earlier in patients with genotype B compared with those with genotype C, and development of cirrhosis occurred less frequently in patients with genotype B compared with those with genotype C. Thus, HBV genotypes may influence the prognosis of HBV‐related chronic liver disease. J. Med. Virol. 70:350–354, 2003. © 2003 Wiley‐Liss, Inc.