Indocyanine green-augmented diode laser treatment of port-wine stains: clinical and histological evidence for a new treatment option from a randomized controlled trial
Summary Background Complete clearance of port‐wine stains (PWS) is difficult to achieve, mainly because of the resistance of small blood vessels to laser irradiation. Indocyanine green (ICG)‐augmented diode laser treatment (ICG+DL) may overcome this problem. Objectives To evaluate the feasibility...
Saved in:
Published in | British journal of dermatology (1951) Vol. 167; no. 2; pp. 333 - 342 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.08.2012
Wiley-Blackwell |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Summary
Background Complete clearance of port‐wine stains (PWS) is difficult to achieve, mainly because of the resistance of small blood vessels to laser irradiation. Indocyanine green (ICG)‐augmented diode laser treatment (ICG+DL) may overcome this problem.
Objectives To evaluate the feasibility of ICG+DL therapy of PWS and to compare the safety and efficacy of ICG+DL with the standard treatment, flashlamp‐pumped pulsed dye laser (FPDL).
Methods In a prospective randomized controlled clinical study, 31 patients with PWS were treated with FPDL (λem = 585 nm, 6 J cm−2, 0·45 ms pulse duration) and ICG+DL (λem = 810 nm, 20–50 J cm−2, 10–25 ms pulse duration, ICG‐concentration: 2 mg kg−1 body weight) in a split‐face modus in one single treatment setting that included histological examination (haematoxylin and eosin, CD34). Two blinded investigators and the patients assessed clearance rate, cosmetic appearance and side‐effects up to 3 months after treatment.
Results ICG+DL therapy induced photocoagulation of medium and large blood vessels (> 20 μm diameter) but not of small blood vessels. According to the investigators’ assessment, clearance rates and cosmetic appearance were better after ICG+DL therapy than after FPDL treatment (P = 0·114, P = 0·291, respectively), although not up to a statistically significant level, whereas patients considered these parameters superior (P = 0·003, P = 0·006, respectively). On a 10‐point scale indicating pain during treatment, patients rated ICG+DL to be more painful (5·81 ± 2·12) than FPDL treatment (1·61 ± 1·84).
Conclusion ICG+DL represents a new and promising treatment modality for PWS, but laser parameters and ICG concentration need to be further optimized. |
---|---|
Bibliography: | ArticleID:BJD10950 istex:25EB81990BE407283E2882938474CB4B639BE02F ark:/67375/WNG-K19R354H-3 Conflicts of interest None declared. Funding sources None. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0007-0963 1365-2133 |
DOI: | 10.1111/j.1365-2133.2012.10950.x |