Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments

As the cellular and molecular bases of immune privilege are elucidated experimentally, the phenomenon emerges as an active and dynamic exercise in immune regulation. Local tissue factors play a key role in the establishment and maintenance of privilege, particularly tissue cytokines and mediators wi...

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Bibliographic Details
Published inCurrent opinion in immunology Vol. 5; no. 3; pp. 428 - 432
Main Author Streilein, J.Wayne
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.1993
Subjects
Animals
Antigens - administration & dosage
Antigens - immunology
Blood-Brain Barrier
Blood-Testis Barrier
Brain - blood supply
Brain - immunology
Cheek
Cricetinae
Dendritic Cells - immunology
Eye - blood supply
Eye - immunology
Graft Survival
Humans
Immune Tolerance - physiology
Male
Mice
Neoplasm Transplantation - immunology
Organ Specificity
Rats
Rats, Inbred Lew - immunology
T-Lymphocyte Subsets - immunology
Testis - immunology
Transforming Growth Factor beta - physiology
Transplantation Immunology
ACAID
TGF
IL
Th
IRBP
PEC
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Summary:As the cellular and molecular bases of immune privilege are elucidated experimentally, the phenomenon emerges as an active and dynamic exercise in immune regulation. Local tissue factors play a key role in the establishment and maintenance of privilege, particularly tissue cytokines and mediators within the local microenvironment, which modify both the induction and expression of immunity to antigens that are introduced into, or arise within, privileged sites.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
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ObjectType-Feature-3
ObjectType-Review-1
ISSN:0952-7915
1879-0372
DOI:10.1016/0952-7915(93)90064-Y