A patient with lichen sclerosus, Langerhans cell histiocytosis, and invasive squamous cell carcinoma of the vulva

• Published in: American journal of obstetrics and gynecology Vol. 203; no. 2; pp. e7 - e10
• Main Authors: Simons, Michiel, MD, Van De Nieuwenhof, Hedwig P., MD, Van Der Avoort, Irene A.M., MD, Bulten, Johan, MD, PhD, De Hullu, Joanne A., MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.08.2010
• Subjects: Adrenal Cortex Hormones - therapeutic use; Adult; Biopsy, Needle; Carcinoma, Squamous Cell - complications; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Cell Transformation, Neoplastic - pathology; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Follow-Up Studies; Gynecologic Surgical Procedures - methods; Histiocytosis, Langerhans-Cell - complications; Histiocytosis, Langerhans-Cell - pathology; Histiocytosis, Langerhans-Cell - therapy; Humans; Immunohistochemistry; Langerhans histiocytosis; lichen sclerosus; Neoplasm Invasiveness - pathology; Obstetrics and Gynecology; Precancerous Conditions - pathology; Radiotherapy, Adjuvant; Treatment Outcome; Vulvar Lichen Sclerosus - complications; Vulvar Lichen Sclerosus - drug therapy; Vulvar Lichen Sclerosus - pathology; Vulvar Neoplasms - complications; Vulvar Neoplasms - pathology; Vulvar Neoplasms - therapy; vulvar squamous cell carcinoma; vulvar squamous cell carcinoma; Langerhans histiocytosis; lichen sclerosus
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2010.04.023

We report a patient with vulvar lichen sclerosus, Langerhans cell histiocytosis (LCH), and later vulvar cancer. In LCH, high amounts of non functional Langerhans cells are present in the affected tissue, making it possible that LCH may have contributed to vulvar cancer development in this patient.