Mechanisms of cardiac conduction: a history of revisions

Cardiac conduction is the process by which electrical excitation spreads through the heart, triggering individual myocytes to contract in synchrony. Defects in conduction disrupt synchronous activation and are associated with life-threatening arrhythmias in many pathologies. Therefore, it is scarcel...

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Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 306; no. 5; pp. H619 - H627
Main Authors Veeraraghavan, Rengasayee, Gourdie, Robert G., Poelzing, Steven
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.03.2014
Subjects
Action Potentials
Animals
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - history
Arrhythmias, Cardiac - physiopathology
Cardiac arrhythmia
Cardiomyocytes
Excitation Contraction Coupling
Heart
Heart Conduction System - physiopathology
History, 20th Century
History, 21st Century
Humans
Models, Cardiovascular
Myocardial Contraction
Pathology
Review
gap junctions
ephaptic coupling
myocardium
modeling
cardiac conduction
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Summary:Cardiac conduction is the process by which electrical excitation spreads through the heart, triggering individual myocytes to contract in synchrony. Defects in conduction disrupt synchronous activation and are associated with life-threatening arrhythmias in many pathologies. Therefore, it is scarcely surprising that this phenomenon continues to be the subject of active scientific inquiry. Here we provide a brief review of how the conceptual understanding of conduction has evolved over the last century and highlight recent, potentially paradigm-shifting developments.
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ISSN:0363-6135
1522-1539
1522-1539
DOI:10.1152/ajpheart.00760.2013