Single Nucleotide Polymorphism at rs7903146 of Transcription Factor 7-like 2 gene Among Subjects with Type 2 Diabetes Mellitus in Myanmar

• Published in: Journal of the ASEAN Federation of Endocrine Societies Vol. 38; no. S1; pp. 41 - 47
• Main Authors: Phu, Sagawah, Thida, Aye, Maung, Kyu Kyu, Chit, Tet Tun
• Format: Journal Article
• Language: English
• Published: Philippines Journal of the ASEAN Federation of Endocrine Societies 01.01.2023; ASEAN Federation of Endocrine Societies
• Subjects: Case-Control Studies; Diabetes Mellitus, Type 2 - epidemiology; Humans; Myanmar; Myanmar - epidemiology; Original; Polymorphism, Single Nucleotide - genetics; SNP; T Cell Transcription Factor 1 - genetics; TCF7L2; Transcription Factor 7-Like 2 Protein - genetics; Myanmar; risk variants; type 2 diabetes; Pashtun population; whole exome sequencing; bioinformatics
• ISSN: 0857-1074; 2308-118X
• DOI: 10.15605/jafes.037.S2

To investigate the association between the single nucleotide polymorphism (SNP) rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes mellitus (T2DM) and to examine the impact of this variant on pancreatic beta-cell function in the Myanmar population. A case-control study was undertaken in 100 subjects with T2DM and 113 controls. The SNP rs7903146 was genotyped using the allele-specific polymerase chain reaction method. Plasma glucose and serum insulin levels were determined using the enzymatic colorimetric method and ELISA respectively. Beta-cell function was calculated by the HOMA-β formula. The frequencies of carrier genotypes (CT and TT) were higher in subjects with T2DM than in controls. The minor T alleles of rs7903146 were found to statistically increase type 2 diabetes risk than the C allele with an allelic odds ratio of 2.07 (95% CI 1.39-3.09, p=0.0004). The mean HOMA-β level of the group with non-carrier genotype (CC) was significantly higher than that of the groups with carrier genotypes (CT and TT) in subjects with T2DM and controls with a p-value of 0.0003 and less than 0.0001, respectively. The rs7903146 variant of the TCF7L2 gene was found to be associated with T2DM and low β-cell function among Myanmar subjects.