Aminophylline therapy in children: Guidelines for dosage

The oral dosage of aminophylline required for therapeutic “trough” serum theophylline levels was studied in 150 children, 16 months to 19 years old (mean 8.28 years). Dosage requirements tended to be higher for children under 10 years, but marked person-to-person variability in the relation of dose...

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Bibliographic Details
Published inThe Journal of pediatrics Vol. 91; no. 2; pp. 325 - 330
Main Authors Rangsithienchai, Pisit, Newcomb, Richard W.
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.01.1977
Subjects
Administration, Oral
Adolescent
Aminophylline - administration & dosage
Aminophylline - blood
Asthma - blood
Asthma - drug therapy
Child
Child, Preschool
Dose-Response Relationship, Drug
Humans
Infant
Theophylline - administration & dosage
Theophylline - blood
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Summary:The oral dosage of aminophylline required for therapeutic “trough” serum theophylline levels was studied in 150 children, 16 months to 19 years old (mean 8.28 years). Dosage requirements tended to be higher for children under 10 years, but marked person-to-person variability in the relation of dose to serum level was seen at all ages. Individual patients generally maintained consistent serum levels when receiving unchanging doses, although intercurrent disease sometimes disrupted this relationship. Individualization of oral dosage based on frequent serum measurements is necessary to maintain theophylline levels in the therapeutic range and to avoid toxicity.
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(77)80845-7