Consumption of fructooligosaccharides does not favorably affect blood glucose and serum lipid concentrations in patients with type 2 diabetes

• Published in: The American journal of clinical nutrition Vol. 69; no. 1; pp. 64 - 69
• Main Authors: Alles, M.S, Roos, N.M. de, Bakx, J.C, Lisdonk, E. van de, Zock, P.L, Hautvast, J.G.A.J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 1999; American Society for Clinical Nutrition, Inc
• Subjects: Acetates - blood; acetic acid; Adults; Afdeling Humane voeding; Biological and medical sciences; Blood; blood glucose; Blood Glucose - drug effects; blood lipids; blood serum; cholesterol; Cross-Over Studies; Diabetes; diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diet therapy; Diabetes. Impaired glucose tolerance; diet; dietary fiber; Dietary Supplements; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; fatty acids; Female; Fructose - administration & dosage; Fructose - pharmacology; Glucose; Glucose - administration & dosage; Glucose - metabolism; high density lipoprotein; Human Nutrition; Human Nutrition & Health; Human Nutrition (HNE); Humane Voeding; Humane Voeding & Gezondheid; Humans; Lipids; Lipids - blood; low density lipoprotein; Male; Medical sciences; men; Middle Aged; oligosaccharides; Oligosaccharides - administration & dosage; Oligosaccharides - pharmacology; patients; Single-Blind Method; triacylglycerols; VLAG; women; Netherlands; Endocrinopathy; Human; Oligosaccharide; Lipids; Acetate; Non insulin dependent diabetes; Cholesterol; Fructose; Feeding; Lipemia; Diet; Triacylglycerol; Adult; Carbohydrate; Glycemia
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/69.1.64

Background: Fructooligosaccharides have been claimed to lower fasting glycemia and serum total cholesterol concentrations, possibly via effects of short-chain fatty acids produced during fermentation. Objective: We studied the effects of fructooligosaccharides on blood glucose, serum lipids, and serum acetate in 20 patients with type 2 diabetes. Design: In a randomized, single-blind, crossover design, patients consumed either glucose as a placebo (4 g/d) or fructooligosaccharides (15 g/d) for 20 d each. Average daily intakes of energy, macronutrients, and dietary fiber were similar with both treatments. Results: Compliance, expressed as the proportion of supplements not returned, was near 100% during both treatments. Fructooligosaccharides did not significantly affect fasting concentrations (mmol/L) of serum total cholesterol (95% CI: -0.07, 0.48), HDL cholesterol (-0.04, 0.04), LDL cholesterol (-0.06, 0.34), serum triacylglycerols (-0.21, 0.44), serum free fatty acids (-0.08, 0.04), serum acetate (-0.01, 0.01), or blood glucose (-0.37, 0.40). Conclusions: We conclude that 20 d of dietary supplementation with fructooligosaccharides had no major effect on blood glucose, serum lipids, or serum acetate in patients with type 2 diabetes. This lack of effect was not due to changes in dietary intake, insufficient statistical power, or noncompliance of the patients.