Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

• Published in: Chemical science (Cambridge) Vol. 11; no. 38; pp. 1421 - 143
• Main Authors: Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei, Yu, Chengzhong
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 10.09.2020; The Royal Society of Chemistry
• Subjects: Antigens; Breast cancer; Cell death; Chemistry; Customization; Immunotherapy; Lymphocytes; Nanoparticles; Nanotechnology; Phosphorylation; Silicon dioxide; Strategy; Tumors
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/d0sc02803g

Post translational modifications (PTM) such as phosphorylation are often correlated with tumorigenesis and malignancy in breast cancer. Herein, we report a PTM-assisted strategy as a simplified version of a personalized cancer vaccine for enhanced cancer immunotherapy. Titanium modified dendritic mesoporous silica nanoparticles (TiDMSN) are applied to assist the specific enrichment of phosphorylated tumor antigens released upon immunogenic cell death. This strategy significantly improved the tumor inhibition efficacy in a bilateral breast cancer model and the expansion of both CD8 + and CD4 + T cells in the distant tumor site. The nanotechnology based PTM-assisted strategy provides a simple and generalizable methodology for effective personalized cancer immunotherapy. The nano-enabled post-translational modification assisted strategy for effective cancer immunotherapy.