Recent advances in polyaniline based biosensors

• Published in: Biosensors & bioelectronics Vol. 26; no. 6; pp. 2811 - 2821
• Main Authors: Dhand, Chetna, Das, Maumita, Datta, Monika, Malhotra, B.D.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 15.02.2011; Elsevier
• Subjects: Aniline Compounds - chemistry; Antibodies, Immobilized; Biological and medical sciences; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Biosensing Techniques - trends; Biosensor; Biosensors; Biotechnology; Cholesterol - analysis; Conducting polymers; Direct electron transfer; DNA - analysis; DNA - genetics; Electric Conductivity; Electrochemical Techniques; Electron Transport; Enzymes, Immobilized; Fundamental and applied biological sciences. Psychology; Glucose - analysis; Humans; Immunosensor; Methods. Procedures. Technologies; Nanostructure; Nucleic Acid Hybridization; Peroxides - analysis; Polyaniline; Various methods and equipments; Conducting polymers; Direct electron transfer; Nanostructure; Polyaniline; Biosensor; Immunosensor; Electron transfer; Aniline polymer
• ISSN: 0956-5663; 1873-4235
• DOI: 10.1016/j.bios.2010.10.017

The present paper contains a detailed overview of recent advances relating to polyaniline (PANI) as a transducer material for biosensor applications. This conducting polymer provides enormous opportunities for binding biomolecules, tuning their bio-catalytic properties, rapid electron transfer and direct communication to produce a range of analytical signals and new analytical applications. Merging the specific nature of different biomolecules (enzymes, nucleic acids, antibodies, etc.) and the key properties of this modern conducting matrix, possible biosensor designs and their biosensing characteristics have been discussed. Efforts have been made to discuss and explore various characteristics of PANI responsible for direct electron transfer leading towards fabrication of mediator-less biosensors.