Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents
Objective The aim of this study was to explore the association of dopamine receptor D2 ( DRD2 ) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up. Methods This retrospective cohort study included obese children and adolescents with a follow-up period of 8 yea...
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Published in | Journal of Zhejiang University. B. Science Vol. 19; no. 10; pp. 807 - 814 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Hangzhou
Zhejiang University Press
01.10.2018
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Objective
The aim of this study was to explore the association of dopamine receptor D2 (
DRD2
) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up.
Methods
This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and
DRD2
polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance.
Results
One hundred and nine obese children and adolescents were included in the current study. Among three
DRD2
single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30‒8.58).
Conclusions
The rs2075654 polymorphism of
DRD2
is related to long-term obesity alleviation in obese Chinese children and adolescents. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding Author |
ISSN: | 1673-1581 1862-1783 |
DOI: | 10.1631/jzus.B1800155 |