Detection of Human Herpesvirus 8 DNA Sequences before the Appearance of Kaposi's Sarcoma in Human Immunodeficiency Virus (HIV)-Positive Subjects with a Known Date of HIV Seroconversion
The presence of human herpesvirus 8 (HHV-8) DNA sequences was sought by polymerase chain reaction (PCR) in peripheral blood mononuclear cells of 4 groups: 6 human immunodeficiency virus (HIV)-infected persons with well-defined dates of seroconversion, during the period between the diagnosis of HIV i...
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Published in | The Journal of infectious diseases Vol. 174; no. 2; pp. 283 - 287 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
The University of Chicago Press
01.08.1996
University of Chicago Press Oxford University Press |
Subjects | |
Online Access | Get full text |
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Summary: | The presence of human herpesvirus 8 (HHV-8) DNA sequences was sought by polymerase chain reaction (PCR) in peripheral blood mononuclear cells of 4 groups: 6 human immunodeficiency virus (HIV)-infected persons with well-defined dates of seroconversion, during the period between the diagnosis of HIV infection and the appearance of Kaposi's sarcoma (KS); 45 HIV-positive persons with no symptoms of HIV infection; 11 AIDS patients with KS; and 14 AIDS patients without KS. HHV-8 DNA PCR was positive in 3 of the 6 patients during HIV infection preceding the appearance of KS and in all but 1 of 11 AIDS patients with KS. HHV-8 DNA PCR was negative in all but 1 of the 45 HIV-positive persons with no symptoms of infection and in all but 1 AIDS patient without KS. These results indicate that HHV-8 DNA may be detected several years before the occurrence of KS in HIV-infected subjects. |
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Bibliography: | istex:AC33318ECA00428849D28F14555B1647EF0F8934 Reprints or correspondence: Dr. Jean-Jacques Lefrère, Institut National de Transfusion Sanguine, 53 Blvd. Diderot, 75012 Paris, France. ark:/67375/HXZ-JW5V9HT5-3 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1093/infdis/174.2.283 |