Expression and Localization of COMMD1 Proteins in Human Placentas from Women with Preeclampsia

• Published in: Yonsei medical journal Vol. 54; no. 2; pp. 494 - 499
• Main Authors: Kwon, Han-Sung, Park, Seung-Hwa, Hwang, Han-Sung, Sohn, In-Sook, Kim, Soo-Nyung
• Format: Journal Article
• Language: English
• Published: Korea (South) Yonsei University College of Medicine 01.03.2013; 연세대학교의과대학
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - isolation & purification; Adaptor Proteins, Signal Transducing - metabolism; Adult; Female; Humans; Original; Placenta - metabolism; Pre-Eclampsia - metabolism; Pregnancy; RNA, Messenger - metabolism; 의학일반
• ISSN: 0513-5796; 1976-2437; 1976-2437
• DOI: 10.3349/ymj.2013.54.2.494

Recently, COMMD1 has been identified as a novel interactor and regulator of hypoxia-inducible factor-1 and nuclear factor kappa B transcriptional activity. The goal of this study was to determine the difference of COMMD1 expression in the placentas of women with normal and preeclamptic (PE) pregnancies. Immnoperoxidase and immunofluorescent staining for COMMD1 was performed on nine normal and nine severe PE placental tissues, and COMMD1 mRNA expression was quantified by quantitative reverse transcription polymerase chain reaction. The expression of mRNA of COMMD1 was significantly higher in the study group than in the control group. The immunoreactivity was higher especially in the syncytiotrophoblast of PE placentas than in the control group. This study demonstrated increased placental COMMD1 expression in women with severe preeclampsia compared to that found in women with normal pregnancies, and this finding might contribute to a better understanding of the pathophysiology of preeclampsia.