Bone morphogenetic proteins and inner ear development

Bone morphogenetic proteins (BMPs) are the largest subfamily of the transforming growth factor-β superfamily, and they play important roles in the development of numerous organs, including the inner ear. The inner ear is a relatively small organ but has a highly complex structure and is involved in...

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Published inJournal of Zhejiang University. B. Science Vol. 20; no. 2; pp. 131 - 145
Main Authors Ma, Jiao-yao, You, Dan, Li, Wen-yan, Lu, Xiao-ling, Sun, Shan, Li, Hua-wei
Format Journal Article
LanguageEnglish
Published Hangzhou Zhejiang University Press 01.02.2019
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Bone morphogenetic proteins
Ear
Growth factors
Hearing loss
Hearing protection
Inner ear
Organs
Proteins
Review
Transforming growth factor
Transforming growth factor-b
Hearing
内耳
R764.3
平衡
听觉
Development
Bone morphogenetic protein (BMP) signaling
发育
Balance
Inner ear
骨形态发生蛋白(BMP)信号通路
Bone morphogenetic protein (BMP) signaling; Development; Inner ear; Hearing; Balance
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Summary:Bone morphogenetic proteins (BMPs) are the largest subfamily of the transforming growth factor-β superfamily, and they play important roles in the development of numerous organs, including the inner ear. The inner ear is a relatively small organ but has a highly complex structure and is involved in both hearing and balance. Here, we discuss BMPs and BMP signaling pathways and then focus on the role of BMP signal pathway regulation in the development of the inner ear and the implications this has for the treatment of human hearing loss and balance dysfunction.
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The two authors contributed equally to this work
Corresponding Authors
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B1800084