Clinical significance of intensity-modulated radiotherapy (IMRT) to the distant metastatic lymph nodes for metastatic cervical cancer

• Published in: BMC cancer Vol. 24; no. 1; pp. 1170 - 7
• Main Authors: Fang, Chi, Liu, Suping, Xia, Jie, Wu, Xiaohua, Zhu, Jun, Ke, Guihao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Cancer therapies; Care and treatment; Cervical cancer; Chemotherapy; Clinical Relevance; Complications and side effects; Distant metastatic lymph nodes; Female; Humans; Intensity-modulated radiotherapy; Lymph nodes; Lymph Nodes - pathology; Lymphatic metastasis; Lymphatic Metastasis - radiotherapy; Lymphatic system; Metastases; Metastasis; Middle Aged; Mortality; Neoplasm Staging; Oncology; Patient outcomes; Patients; Peritoneum; Prognosis; Radiation therapy; Radiotherapy, Intensity-Modulated - methods; Response rates; Retrospective Studies; Survival; Survival analysis; Uterine Cervical Neoplasms - mortality; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy; China; Distant metastatic lymph nodes; Intensity-modulated radiotherapy; Survival; Cervical cancer
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-024-12895-2

To retrospectively explore the clinical significance of radiotherapy to the distant metastatic lymph nodes (cervical/ clavicular/ mediastinal et al.) in metastatic cervical cancer. Hereinto, these cervicothoracic lymph nodes were metastasized from IB1-IVA (initial stage at first treatment), and IVB initially had metastatic disease in these areas at diagnosis. Metastatic cervical cancer only with the distant cervicothoracic metastatic lymph nodes (cervical/ clavicular/ mediastinal et al.), without distant parenchymal organs metastasis such as lung, liver, bone, and peritoneum, were enrolled in the analysis. These patients were classified into IB1-IVA and IVB based on their initial stage of first treatment. All patients received IMRT for the distant metastatic lymph nodes. The progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Overall, the median PFS was 9 months, and the median OS was 27 months. The subgroup analysis showed that for IB1-IVA, the median PFS was 11 months, and the median OS was 30.5 months. For IVB, the median PFS was 8 months, and the median OS was 16 months. Radiotherapy is beneficial to the distant metastatic lymph nodes (cervical/ clavicular/ mediastinal et al.), and could effectively bring the longer PFS and OS for metastatic cervical cancer.