Recent results on functional polymers and macromonomers of interest as biomaterials or for biomaterial modification

• Published in: Biomaterials Vol. 15; no. 15; pp. 1235 - 1241
• Main Authors: Ferruti, P., Ranucci, E., Sartore, L., Bignotti, F., Marchisio, M.A., Bianciardi, P., Veronese, F.M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.1994
• Subjects: Biocompatible Materials - chemistry; Macromonomers; multifunctional polymers; poly(acryloyl morpholine); poly(amidoamines); poly(vinylpyrrolidinone); Polyamines - chemistry; Polymers - chemistry; poly(vinylpyrrolidinone); Macromonomers; poly(amidoamines); poly(acryloyl morpholine); multifunctional polymers
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/0142-9612(94)90275-5

Different families of functionalized polymers with potential as biomaterials, or for biomaterial modification, have been investigated. In particular, degradation studies have been performed on poly(amidoamines), a family of polymers obtained by polyaddition of amines to bisacrylamides, and endowed with heparin-complexing ability. Some new poly(amidoamines) with more resistance towards hydrolytic degradation than traditional ones have been discovered. Other ter-amino polymers deriving from the polyaddition of ter-amino functionalized bis-thiols to bis-acrylic esters, or other activated unsaturated compounds, have been studied. Their quaternarization products have been proven, in a parallel work, to act as powerful antimicrobial agents. By performing in situ the polyaddition reaction, semi-interpenetrated networks based on silicone rubber and the same polymers have been prepared. Finally, end-functionalized amphiphilic oligomers have been prepared by radical polymerization techniques, and their use for enzyme modification considered. Biomaterials (1994) 15, 1235–1241