Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle
Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance in domestic animals, we sequenced the genomes of 28 cattle from warm and cold areas across China. By characterizing the population structure and demographi...
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Published in | Dōngwùxué yánjiū Vol. 43; no. 2; pp. 275 - 284 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
China
Kunming Institute of Zoology, The Chinese Academy of Sciences
18.03.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance in domestic animals, we sequenced the genomes of 28 cattle from warm and cold areas across China. By characterizing the population structure and demographic history, we identified two genetic clusters, i.e., northern and southern groups, as well as a common historic population peak at 30 kilo years ago. Genomic scan of cold-tolerant breeds determined potential candidate genes in the thermogenesis-related pathways that were under selection. Specifically, functional analysis identified a substitution of
(p.P779L) in northern cattle, which maintains brown adipocyte formation by boosting thermogenesis-related gene expression, indicating a vital role of this gene in cold tolerance. These findings provide a basis for genetic variation in domestic cattle shaped by environmental temperature and highlight the role of reverse mutation in livestock species. |
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ISSN: | 2095-8137 0254-5853 |
DOI: | 10.24272/j.issn.2095-8137.2021.360 |