Artificial neural network modeling to predict the plasma concentration of aminoglycosides in burn patients

• Published in: Biomedicine & pharmacotherapy Vol. 58; no. 4; pp. 239 - 244
• Main Authors: Yamamura, Shigeo, Kawada, Keiko, Takehira, Rieko, Nishizawa, Kenji, Katayama, Shirou, Hirano, Masaaki, Momose, Yasunori
• Format: Journal Article
• Language: English
• Published: Paris Elsevier SAS 01.05.2004; Elsevier
• Subjects: Adult; Aged; Aged, 80 and over; Aminoglycoside antibiotics; Aminoglycosides - blood; Aminoglycosides - pharmacokinetics; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Artificial neural network modeling; Biological and medical sciences; Burn severity; Burns - blood; Burns - drug therapy; Dibekacin - analogs & derivatives; Dibekacin - blood; Dibekacin - pharmacokinetics; Female; Fluorescence Polarization Immunoassay; Humans; Infusions, Intravenous; Linear Models; Logistic Models; Male; Medical sciences; Middle Aged; Neural Networks (Computer); Pharmacokinetic modeling; Pharmacology. Drug treatments; Aminoglycoside antibiotics; Artificial neural network modeling; Pharmacokinetic modeling; Burn severity; Human; Biological fluid; Neural network; Modeling; Blood plasma; Burn; Antibiotic; Aminoglycoside; Artifical neural network modeling; Pharmacokinetics
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2003.12.012

The goal was to use an artificial neural network model to predict the plasma concentration of aminoglycosides in burn patients and identify patients whose plasma antibiotic concentration would be sub-therapeutic based on the patients’ physiological data and taking into account burn severity. Physiological data and some indicators of burn severity were collected from 30 burn patients who received arbekacin. A three-layer artificial neural network with five neurons in the hidden layer was used to predict the plasma concentration of arbekacin. Linear modeling for prediction of plasma concentration and logistic regression modeling for the classification of patients were also used and the predictive performance was compared to results from the artificial neural network model. Dose, body mass index, serum creatinine concentration and amount of parenteral fluid were selected as covariates for the plasma concentration of arbekacin. Area of burn after skin graft was a good covariate for indicating burn severity. Predictive performance of the artificial neural network model including burn severity was much better than linear modeling and logistic regression analysis. An artificial neural network model should be helpful for the prediction of plasma concentration using patients’ physiological data, and burn severity should be included for improved prediction in burn patients. Because the relationship between burn severity and plasma concentration of aminoglycosides is thought to be nonlinear, it is not surprising that the artificial neural network model showed better predictive performance compared to the linear or logistic regression models.