The Impact of Microbiota on the Gut–Brain Axis: Examining the Complex Interplay and Implications

• Published in: Journal of clinical medicine Vol. 12; no. 16; p. 5231
• Main Authors: Chaudhry, Tuba Shahid, Senapati, Sidhartha Gautam, Gadam, Srikanth, Mannam, Hari Priya Sri Sai, Voruganti, Hima Varsha, Abbasi, Zainab, Abhinav, Tushar, Challa, Apurva Bhavana, Pallipamu, Namratha, Bheemisetty, Niharika, Arunachalam, Shivaram P
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2023; MDPI
• Subjects: Autism; Bacteria; Behavior; Brain research; Central nervous system; Clinical medicine; Cognition & reasoning; Cytokines; Development and progression; Gastrointestinal system; Health aspects; Homeostasis; Immunology; Influence; Intestine, Small; Metabolism; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Motility; Nervous system; Nervous system diseases; Nervous system, Autonomic; Neurotransmitters; Parkinson's disease; Pathogenesis; Permeability; Physiological aspects; Review; United States
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12165231

The association and interaction between the central nervous system (CNS) and enteric nervous system (ENS) is well established. Essentially ENS is the second brain, as we call it. We tried to understand the structure and function, to throw light on the functional aspect of neurons, and address various disease manifestations. We summarized how various neurological disorders influence the gut via the enteric nervous system and/or bring anatomical or physiological changes in the enteric nervous system or the gut and vice versa. It is known that stress has an effect on Gastrointestinal (GI) motility and causes mucosal erosions. In our literature review, we found that stress can also affect sensory perception in the central nervous system. Interestingly, we found that mutations in the neurohormone, serotonin (5-HT), would result in dysfunctional organ development and further affect mood and behavior. We focused on the developmental aspects of neurons and cognition and their relation to nutritional absorption via the gastrointestinal tract, the development of neurodegenerative disorders in relation to the alteration in gut microbiota, and contrariwise associations between CNS disorders and ENS. This paper further summarizes the synergetic relation between gastrointestinal and neuropsychological manifestations and emphasizes the need to include behavioral therapies in management plans.