Biological Mechanisms Influencing Prosthetic Bypass Graft Patency: Possible Targets for Modern Graft Design

• Published in: European journal of vascular and endovascular surgery Vol. 43; no. 1; pp. 66 - 72
• Main Authors: Scharn, D.M, Daamen, W.F, van Kuppevelt, T.H, van der Vliet, J.A
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2012
• Subjects: Animals; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation - adverse effects; Blood Vessel Prosthesis Implantation - instrumentation; Coated Materials, Biocompatible; Graft engineering; Graft Occlusion, Vascular - etiology; Graft Occlusion, Vascular - pathology; Graft Occlusion, Vascular - physiopathology; Graft Occlusion, Vascular - prevention & control; Graft patency; Humans; Hyperplasia; Infrainguinal prothetic bypass graft surgery; Intimal hyperplasia; Prosthesis Design; Surgery; Thrombosis - etiology; Thrombosis - pathology; Thrombosis - physiopathology; Thrombosis - prevention & control; Vascular Patency; Graft engineering; Graft patency; Intimal hyperplasia; Infrainguinal prothetic bypass graft surgery
• ISSN: 1078-5884; 1532-2165
• DOI: 10.1016/j.ejvs.2011.09.009

Abstract In recent years, ample attention has been directed towards the mechanisms that play a major role in the process of vascular graft failure, especially graft thrombosis and intimal narrowing have been highlighted. In this article, a survey is conducted into the key mechanisms of the biological processes of intimal hyperplasia and ultimate graft failure. The sequence of biochemical events that lead to thrombosis of grafts is used as a guideline to describe possible counteracting prosthetic surface interventions in each separate phase of the process.