Autosomal dominant polycystic kidney disease in Persian and Persian-cross cats

• Published in: Veterinary pathology Vol. 34; no. 2; pp. 117 - 126
• Main Authors: Eaton, K.A. (Ohio State University, Columbus.), Biller, D.S, DiBartola, S.P, Radin, M.J, Wellman, M.L
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.03.1997
• Subjects: Animals; ATPASA; ATPASE; BREEDS (ANIMALS); Bromodeoxyuridine - metabolism; Cat Diseases - metabolism; Cat Diseases - pathology; CATS; CHAT; Crosses, Genetic; CYSTS; DISEASE COURSE; ENFERMEDADES RENALES; EPITELIO; EPITHELIUM; Epithelium - chemistry; Epithelium - pathology; GATO; GENETIC DISORDERS; Immunohistochemistry; INSPECCION POSTMORTEM; KIDNEY DISEASES; KIDNEYS; KYSTE; Lectins - chemistry; MORPHOLOGY; NECROPSIE; NEPHROPATHIE; PATHOGENESE; PATHOGENESIS; PATOGENESIS; Polycystic Kidney, Autosomal Dominant - chemistry; Polycystic Kidney, Autosomal Dominant - pathology; Polycystic Kidney, Autosomal Dominant - veterinary; POSTMORTEM EXAMINATION; QUISTES; RACE (ANIMAL); RAZAS (ANIMALES); REIN; RINONES; Sodium - metabolism; Sodium-Potassium-Exchanging ATPase - analysis; TRASTORNOS GENETICOS; TROUBLE GENETIQUE; Persian cats; immunohistochemistry; bromodeoxyuridine; Na/K ATPase; Autosomal dominant polycystic kidney disease; lectin
• ISSN: 0300-9858; 1544-2217
• DOI: 10.1177/030098589703400204

A form of autosomal dominant polycystic kidney disease (ADPKD) similar in clinical features to human ADPKD occurs in the Persian cat. We characterized the morphologic and immunohistochemical features of this disease in a colony of affected cats. Complete postmortem examinations were performed on 11 normal and 22 affected cats ranging in age from 3 months to 10 years. Kidneys were evaluated by gross and histologic examination, ultrastructure, lectin staining, bromodeoxyuridine immunochemistry for labeling index, and immunochemistry for distribution of Na/K ATPase. Feline ADPKD was characterized by variable numbers of cysts in the renal cortex and medulla. Ultrastructural examination and lectin staining suggested that cysts arose from proximal and distal nephron segments. Bromodeoxyuridine labeling demonstrated increased proliferation of epithelium lining some cysts in young cats. Immunohistochemical staining showed variable translocation of Na/K ATPase from the basolateral membranes of cyst-lining cells to the cytoplasm or luminal membranes. Cystic renal disease commonly was associated with chronic tubulointerstitial nephritis and hepatobiliary hyperplasia and fibrosis. Focal hyperplasia of renal tubular epithelium, hepatic cysts, and cardiac lesions were present in some cats. Feline ADPKD shares many morphologic and pathogenetic features with human ADPKD.