Dynamic thiol/disulfide homeostasis in children with attention deficit hyperactivity disorder and its relation with disease subtypes

Abstract Background The aim of this study was to evaluate a novel oxidative stress marker (thiol/disulfide homeostasis) in attention deficit hyperactivity disorder (ADHD) children for the first time in literature. Methods Ninety children with ADHD diagnosed according to DSM-V and as control group, 6...

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Published inComprehensive psychiatry Vol. 73; pp. 53 - 60
Main Authors Avcil, Sibelnur, Uysal, Pınar, Avcil, Mucahit, Alışık, Murat, Biçer, Cemile
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2017
Elsevier Limited
Subjects
Adolescent
Alzheimer's disease
Antioxidants
Attention Deficit Disorder with Hyperactivity - blood
Attention Deficit Disorder with Hyperactivity - diagnosis
Attention deficit hyperactivity disorder
Automation
Biomarkers - blood
Case-Control Studies
Chemical bonds
Child
Child & adolescent psychiatry
Children & youth
Diabetes
Disulfides - blood
Enzymes
Female
Females
Homeostasis
Humans
Hyperactivity
Male
Oxidation
Oxidative stress
Proteins
Psychiatry
Sex Characteristics
Signal transduction
Studies
Sulfhydryl Compounds - blood
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Summary:Abstract Background The aim of this study was to evaluate a novel oxidative stress marker (thiol/disulfide homeostasis) in attention deficit hyperactivity disorder (ADHD) children for the first time in literature. Methods Ninety children with ADHD diagnosed according to DSM-V and as control group, 65 healthy children were included to the study. Native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol were compared between the groups. Results Total and native thiol levels were significantly higher whereas the disulfide/native thiol ratios were significantly lower in children with ADHD. ADHD combined type appeared to have higher disulfide, disulfide/native thiol and disulfide/total thiol ratios compared to other subtypes. Disulfide levels of the males with ADHD were significantly higher than those of the females with ADHD. Conclusion This study suggests that thiol/disulfide homeostasis is abnormal in children with ADHD. It may be used as a novel OS marker in ADHD children because it is easy, practical, fully automated and relatively inexpensive.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0010-440X
1532-8384
DOI:10.1016/j.comppsych.2016.11.003