Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol

• Published in: International journal of molecular sciences Vol. 24; no. 19; p. 14717
• Main Authors: Novoskoltseva, Olga A., Litmanovich, Ekaterina A., Loiko, Nataliya G., Nikolaev, Yury A., Yaroslavov, Alexander A.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2023; MDPI
• Subjects: 4-hexylresorcinol; Aqueous solutions; Backup software; biocidal activity; Biocides; Biomedical materials; Cellulose; Coatings; composite coating; Ethanol; Hydrogen bonds; Incorporation; interpolyelectrolyte complex; Polymers; polysaccharide; Skin; Surface active agents; Transplants & implants; Russia
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms241914717

Biocidal coatings have been used in biomedicine, cosmetology and the food industry. In this article, the coatings are described as being composed of non-stoichiometric polycomplexes, products of electrostatic coupling of two commercial biodegradable ionic polymers, anionic sodium alginate and cationic quaternized hydroxyethyl cellulose ethoxylate. Non-stoichiometric polycomplexes with a 5-fold excess of the cationic polymer were used for immobilizing hydrophobic biocidal 4-hexylresorcinol (HR). Being dispersed in water, the polycomplex particles were capable of absorbing a tenfold excess of HR in relation to the polycation. After deposition onto the plastic surface and drying, the aqueous polycomplex–HR composite formulation forms a transparent homogeneous coating, which swells slightly in water. The interpolyelectrolyte complex (IPEC) is substantially non-toxic. The incorporation of HR in the IPEC imparts antimicrobial activity to the resulting composite, in both aqueous solutions and coatings, against Gram-negative and Gram-positive bacteria and yeast. The polysaccharide-based polycomplexes with embedded HR are promising for the fabrication of biocidal films and coatings.