Qualitative and quantitative effects on the morphology of the small intestine after multiple daily fractionation

The behaviour of qualitative and quantitative morphologic parameters in rats exposed on the abdomen only to multiple daily fractionation (MDF) of 3 Gy X 2 and 3 Gy X 2 X 2 with 12 h splits was analyzed. Both doses were sublethal. The number of epithelial cells in the crypts and in the whole formatio...

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Bibliographic Details
Published inActa radiologica. Oncology Vol. 23; no. 5; p. 353
Main Authors Becciolini, A, Cremonini, D, Fabbrica, D, Balzi, M
Format Journal Article
LanguageEnglish
Published Sweden 1984
Subjects
Animals
Cell Count
Cell Division - radiation effects
Epithelium - pathology
Epithelium - radiation effects
Female
Gamma Rays
Intestine, Small - pathology
Intestine, Small - radiation effects
Mitotic Index - radiation effects
Radiation Dosage
Rats
Rats, Inbred Strains
Time Factors
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Summary:The behaviour of qualitative and quantitative morphologic parameters in rats exposed on the abdomen only to multiple daily fractionation (MDF) of 3 Gy X 2 and 3 Gy X 2 X 2 with 12 h splits was analyzed. Both doses were sublethal. The number of epithelial cells in the crypts and in the whole formation, the mitotic index, and the labelling index appeared to be markedly reduced at early intervals after irradiation. Repair and recovery quickly led to normal morphology. The effects of an 8 Gy single dose were compared with those from multiple fractionations.
ISSN:0349-652X
DOI:10.3109/02841868409136033