A sensitive method for the detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100
‘Classical nitroreductase’ is an enzyme involved in the intracellular metabolic activation of mutagenic nitroarenes. The nitroreductase gene of Salmonella typhimurium TA1538 was cloned into pBR322 and the plasmids harboring the gene were introduced into TA98 and TA100. The resulting strains (YG1021...
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| Published in | Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 216; no. 4; pp. 211 - 220 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.08.1989
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| Abstract | ‘Classical nitroreductase’ is an enzyme involved in the intracellular metabolic activation of mutagenic nitroarenes. The nitroreductase gene of
Salmonella typhimurium TA1538 was cloned into pBR322 and the plasmids harboring the gene were introduced into TA98 and TA100. The resulting strains (YG1021 and YG1026) had more than 50 times higher nitrofurazone-reductase activity than TA1538 containing pBR322, and were extremely sensitive to the mutagenic action of 2-nitrofluorene, 1-nitropyrene and 2-nitronaphthalene. These results indicate that the new strains permit the efficient detection of mutagenic nitroarenes. |
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| AbstractList | ‘Classical nitroreductase’ is an enzyme involved in the intracellular metabolic activation of mutagenic nitroarenes. The nitroreductase gene of
Salmonella typhimurium TA1538 was cloned into pBR322 and the plasmids harboring the gene were introduced into TA98 and TA100. The resulting strains (YG1021 and YG1026) had more than 50 times higher nitrofurazone-reductase activity than TA1538 containing pBR322, and were extremely sensitive to the mutagenic action of 2-nitrofluorene, 1-nitropyrene and 2-nitronaphthalene. These results indicate that the new strains permit the efficient detection of mutagenic nitroarenes. 'Classical nitroreductase' is an enzyme involved in the intracellular metabolic activation of mutagenic nitroarenes. The nitroreductase gene of Salmonella typhimurium TA1538 was cloned into pBR322 and the plasmids harboring the gene were introduced into TA98 and TA100. The resulting strains (YG1021 and YG1026) had more than 50 times higher nitrofurazone-reductase activity than TA1538 containing pBR322, and were extremely sensitive to the mutagenic action of 2-nitrofluorene, 1-nitropyrene and 2-nitronaphthalene. These results indicate that the new strains permit the efficient detection of mutagenic nitroarenes. |
| Author | Nohmi, Takehiko Ishidate, Motoi Watanabe, Masahiko |
| Author_xml | – sequence: 1 givenname: Masahiko surname: Watanabe fullname: Watanabe, Masahiko – sequence: 2 givenname: Motoi surname: Ishidate fullname: Ishidate, Motoi – sequence: 3 givenname: Takehiko surname: Nohmi fullname: Nohmi, Takehiko |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2668749$$D View this record in MEDLINE/PubMed |
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| Keywords | Nitroarenes Salmonella typhimurium Cloning Mutagenecity Nitroreductase |
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| Snippet | ‘Classical nitroreductase’ is an enzyme involved in the intracellular metabolic activation of mutagenic nitroarenes. The nitroreductase gene of
Salmonella... 'Classical nitroreductase' is an enzyme involved in the intracellular metabolic activation of mutagenic nitroarenes. The nitroreductase gene of Salmonella... |
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| SubjectTerms | Cloning Cloning, Molecular Cytosol Genes, Bacterial Mutagenecity Mutagens - analysis Nitro Compounds - analysis Nitroarenes Nitroreductase Nitroreductases - biosynthesis Nitroreductases - genetics Oxidoreductases - biosynthesis Plasmids Restriction Mapping Salmonella typhimurium Salmonella typhimurium - enzymology Species Specificity Transformation, Bacterial |
| Title | A sensitive method for the detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100 |
| URI | https://dx.doi.org/10.1016/0165-1161(89)90007-1 https://www.ncbi.nlm.nih.gov/pubmed/2668749 |
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