Telomere Lengths in Dogs Decrease with Increasing Donor Age

• Published in: The Journal of nutrition Vol. 132; no. 6; pp. 1604S - 1606S
• Main Authors: McKevitt, Tom P., Nasir, Lubna, Argyle, David J., Devlin, Pauline
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.06.2002; American Society for Nutritional Sciences; American Institute of Nutrition
• Subjects: Age; Aging - genetics; Animals; Beagle; Biological and medical sciences; blood; Cellular biology; Chromatin. Chromosome; DNA; dog; Dogs; Dogs - genetics; Fundamental and applied biological sciences. Psychology; in vivo studies; Labrador Retriever; longevity; Molecular and cellular biology; Molecular genetics; Monocytes - physiology; Proteins; Restriction Mapping; senescence; Species Specificity; telomere; Telomere - genetics; telomeres; FISH; TRF; dog; PBMC; age; telomere; Fissipedia; Carnivora; Vertebrata; Senescence; Mammalia; Attrition; Dog; Telomere; Age
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/132.6.1604S

In vitro and in vivo studies of human tissues have demonstrated telomeric attrition with age and have linked this attrition to cellular senescence and aging. Telomere studies in canine subjects have not thus far consistently uncovered the same pattern of telomere attrition that would be expected bec...