Telomere Lengths in Dogs Decrease with Increasing Donor Age

In vitro and in vivo studies of human tissues have demonstrated telomeric attrition with age and have linked this attrition to cellular senescence and aging. Telomere studies in canine subjects have not thus far consistently uncovered the same pattern of telomere attrition that would be expected bec...

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Published inThe Journal of nutrition Vol. 132; no. 6; pp. 1604S - 1606S
Main Authors McKevitt, Tom P., Nasir, Lubna, Argyle, David J., Devlin, Pauline
Format Journal Article Conference Proceeding
LanguageEnglish
Published Bethesda, MD Elsevier Inc 01.06.2002
American Society for Nutritional Sciences
American Institute of Nutrition
Subjects
Age
Aging - genetics
Animals
Beagle
Biological and medical sciences
blood
Cellular biology
Chromatin. Chromosome
DNA
dog
Dogs
Dogs - genetics
Fundamental and applied biological sciences. Psychology
in vivo studies
Labrador Retriever
longevity
Molecular and cellular biology
Molecular genetics
Monocytes - physiology
Proteins
Restriction Mapping
senescence
Species Specificity
telomere
Telomere - genetics
telomeres
FISH
TRF
dog
PBMC
age
telomere
Fissipedia
Carnivora
Vertebrata
Senescence
Mammalia
Attrition
Dog
Telomere
Age
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Summary:In vitro and in vivo studies of human tissues have demonstrated telomeric attrition with age and have linked this attrition to cellular senescence and aging. Telomere studies in canine subjects have not thus far consistently uncovered the same pattern of telomere attrition that would be expected because of the end replication problem. In this report we describe the investigation of telomere lengths in a broad age range of dogs from three different breeds: the Labrador Retriever, Miniature Schnauzer and Beagle. Peripheral blood mononuclear cell–derived DNA samples were subjected to terminal restriction fragment (TRF) analysis and demonstrated a range of mean TRFs from 9.7 to 22.3 kbp. Telomeric attrition tended to be associated with increasing donor age (P = 0.06). Interbreed differences in mean TRF values were also noted (P = 0.006). These results warrant further investigation of possible interbreed differences, given that shorter telomeres may contribute to differing life expectancy between breeds.
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ISSN:0022-3166
1541-6100
DOI:10.1093/jn/132.6.1604S