Differences and the relationship in default mode network intrinsic activity and functional connectivity in mild Alzheimer's disease and amnestic mild cognitive impairment

• Published in: Brain connectivity Vol. 4; no. 8; pp. 567 - 574
• Main Authors: Weiler, Marina, Teixeira, Camila Vieira Ligo, Nogueira, Mateus Henrique, de Campos, Brunno Machado, Damasceno, Benito Pereira, Cendes, Fernando, Balthazar, Marcio Luiz Figueredo
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.10.2014
• Subjects: Aged; Alzheimer Disease - physiopathology; Amnesia - physiopathology; Brain - physiopathology; Case-Control Studies; Cognitive Dysfunction - physiopathology; Female; Frontal Lobe - physiopathology; Gyrus Cinguli - physiopathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net - physiopathology; Parietal Lobe - physiopathology; Special Section on Alzheimer's Disease; Temporal Lobe - physiopathology; episodic memory; functional MRI; dementia; amnestic mild cognitive impairment; Alzheimer's disease
• ISSN: 2158-0014; 2158-0022
• DOI: 10.1089/brain.2014.0234

There is evidence that the default mode network (DMN) functional connectivity is impaired in Alzheimer's disease (AD) and few studies also reported a decrease in DMN intrinsic activity, measured by the amplitude of low-frequency fluctuations (ALFFs). In this study, we analyzed the relationship between DMN intrinsic activity and functional connectivity, as well as their possible implications on cognition in patients with mild AD and amnestic mild cognitive impairment (aMCI) and healthy controls. In addition, we evaluated the differences both in connectivity and ALFF values between these groups. We recruited 29 controls, 20 aMCI, and 32 mild AD patients. To identify the DMN, functional connectivity was calculated by placing a seed in the posterior cingulate cortex (PCC). Within the DMN mask obtained, we calculated regional average ALFFs. Compared with controls, aMCI patients showed decreased ALFFs in the temporal region; compared with AD, aMCI showed higher values in the PCC but lower in the temporal area. The mild AD group had lower ALFFs in the PCC compared with controls. There was no difference between the connectivity in the aMCI group compared with the other groups, but AD patients showed decreased connectivity in the frontal, parietal, and PCC. Also, PCC ALFFs correlated to functional connectivity in nearly all subregions. Cognitive tests correlated to connectivity values but not to ALFFs. In conclusion, we found that DMN connectivity and ALFFs are correlated in these groups. Decreased PCC ALFFs disrupt the DMN functional organization, leading to cognitive problems in the AD spectrum.