Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis

• Published in: Biochemical and biophysical research communications Vol. 411; no. 4; pp. 714 - 720
• Main Authors: Yang, Ming-Hui, Chu, Pei-Yu, Chen, Sharon Chia-Ju, Chung, Tze-Wen, Chen, Wen-Cheng, Tan, Lia-Beng, Kan, Wei-Chih, Wang, Hsien-Yi, Su, Shih-Bin, Tyan, Yu-Chang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.08.2011
• Subjects: ADAM Proteins - metabolism; ADAM Proteins - urine; Aged; Aged, 80 and over; Amino Acid Sequence; Arsenic - urine; Biomarker; biomarkers; Biomarkers, Tumor - metabolism; bladder; Bladder cancer; Blotting, Western; carcinoma; Carcinoma, Transitional Cell - metabolism; Carcinoma, Transitional Cell - pathology; Carcinoma, Transitional Cell - urine; Female; Humans; Male; Middle Aged; Molecular Sequence Data; peptides; Protein identification; proteins; proteome; Proteome - metabolism; Proteomics; Taiwan; urinary bladder neoplasms; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - urine; Urinary protein; urinary tract diseases; urine; Western blotting; Taiwan; Protein identification; Biomarker; Bladder cancer; Urinary protein; Proteomics

► The aim of this study is to utilize proteomic approach to establish urinary protein patterns of bladder cancer. ► In this study, the arsenic concentrations in the urine of bladder cancer patients were still significantly higher than control group. ► Search for new biomarkers for the early detectio...