Halloysite nanotube nanocomposite hydrogels with tunable mechanical properties and drug release behavior

• Published in: Composites science and technology Vol. 85; pp. 126 - 130
• Main Authors: Tu, Jiaxing, Cao, Zheng, Jing, Yihan, Fan, Changjiang, Zhang, Chao, Liao, Liqiong, Liu, Lijian
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 21.08.2013; Elsevier
• Subjects: A. Nanoclays; A. Nanocomposites; Applied sciences; B. Mechanical properties; Biological and medical sciences; Carbonates; Composites; Drugs; Exact sciences and technology; Forms of application and semi-finished materials; General pharmacology; Hydrogel; Hydrogels; Mechanical properties; Medical sciences; Nanocomposites; Nanomaterials; Nanostructure; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymer industry, paints, wood; Technology of polymers; Transport; A. Nanoclays; B. Mechanical properties; A. Nanocomposites; Hydrogel; Biological properties; Nanotube; Uronide polymer; Drug carrier; Compressive strength; Composite material; Colloidal gel; Photopolymerization; Biocompatibility; Carbonate copolymer; Acrylate copolymer; Nanocomposite; Release; Clay; Control release polymer; Mechanical properties; Serum albumin; Alginates; Ethylene oxide copolymer; Experimental study; Protein; Polyelectrolyte; Ultraviolet radiation; Oside polymer; Prepolymer
• ISSN: 0266-3538; 1879-1050
• DOI: 10.1016/j.compscitech.2013.06.011

Nanocomposite hydrogels with tunable mechanical properties and drug release behavior were prepared by halloysite nanotube (HNT), oligo(trimethylene carbonate)–poly(ethylene glycol)–oligo(trimethylene carbonate) diacrylate (TPT), and alginate sodium (AG). The mechanical properties of the hydrogel were greatly enhanced by the addition of small amount of HNT (2wt%). The drug release behavior of the hydrogels was examined using bovine serum albumin (BSA) as model drug, and TPT hydrogel showed a fickcian diffusion controlled release mechanism, while the BSA transport mechanism in TPT-HNT, TPT-AG, and TPT-AG-HNT hydrogels were anomalous transport. The cytocompatibility of the hydrogel were verified by the MTT assay, and the hydrogel showed comparable cytocompatibility with the widely recognized poly(ethylene glycol) hydrogel.