Intermittent Calorie Restriction Delays Prostate Tumor Detection and Increases Survival Time in TRAMP Mice

• Published in: Nutrition and cancer Vol. 61; no. 2; pp. 265 - 275
• Main Authors: Bonorden, Melissa J.L, Rogozina, Olga P, Kluczny, Christina M, Grossmann, Michael E, Grambsch, Patricia L, Grande, Joseph P, Perkins, Susan, Lokshin, Anna, Cleary, Margot P
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.01.2009; Taylor& Francis
• Subjects: adenocarcinoma; Adiponectin - blood; Aging; animal models; Animals; anticarcinogenic activity; Biological and medical sciences; Body Composition; Caloric Restriction; carcinogenesis; Diet; disease detection; experimental diets; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Genotype; Gynecology. Andrology. Obstetrics; Insulin - blood; Insulin-Like Growth Factor I - analysis; Leptin - blood; low calorie diet; Male; Male genital diseases; Medical sciences; Mice; Mice, Transgenic; mortality; Neoplasm Metastasis; Nephrology. Urinary tract diseases; prostatic neoplasms; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; protective effect; Survival Rate; Time Factors; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Prostate tumor; Urinary system disease; Prostate disease; Rodentia; Increase; Survival; Feeding; Vertebrata; Mammalia; Cancerology; Mouse; Intermittent; Animal; Detection; Male genital diseases; Low calorie diet
• ISSN: 0163-5581; 1532-7914
• DOI: 10.1080/01635580802419798

Prostate cancer is the most frequently diagnosed cancer in men. Whereas chronic calorie restriction (CCR) delays prostate tumorigenesis in some rodent models, the impact of intermittent caloric restriction (ICR) has not been determined. Here, transgenic adenocarcinoma of the mouse prostate (TRAMP) mice were used to compare how ICR and CCR affected prostate cancer development. TRAMP mice were assigned to ad libitum (AL), ICR (2 wk 50% AL consumption followed by 2 wk pair feeding to AL consumption), and CCR (25% AL consumption) groups at 7 wk of age and followed until disease burden necessitated euthanasia or mice reached terminal endpoints (48 or 50 wk of age). Body weights fluctuated in response to calorie intake (P < 0.0001). ICR mice were older at tumor detection than AL (P = 0.0066) and CCR (P = 0.0416) mice. There was no difference for age of tumor detection between AL and CCR mice (P = 0.3960). Similar results were found for survival. Serum leptin, adiponectin, insulin, and IGF-I were all significantly different among the groups. These results indicate that the way in which calories are restricted impacts both time to tumor detection and survival in TRAMP mice, with ICR providing greater protective effect compared to CCR.