CXC chemokines in angiogenesis of cancer

The CXC chemokine family are unique cytokines known for their ability to have dual functions in the regulation of angiogenesis related to the following: (1) the presence or absence of the structural/functional motif (Glutamic acid-Leucine-Arginine; ‘ELR’ motif) that immediately precedes the first cy...

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Published inSeminars in cancer biology Vol. 14; no. 3; pp. 195 - 200
Main Authors Strieter, Robert M, Belperio, John A, Phillips, Roderick J, Keane, Michael P
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2004
Subjects
Angiogenesis
Cancer
Chemokines, CXC - physiology
CXC chemokines
Humans
Neoplasms - blood supply
Neovascularization, Pathologic
Tumor growth
Angiogenesis
Tumor growth
CXC chemokines
Cancer
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ISSN1044-579X
1096-3650
DOI10.1016/j.semcancer.2003.10.006

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Summary:The CXC chemokine family are unique cytokines known for their ability to have dual functions in the regulation of angiogenesis related to the following: (1) the presence or absence of the structural/functional motif (Glutamic acid-Leucine-Arginine; ‘ELR’ motif) that immediately precedes the first cysteine amino acid residue in the primary structure of these chemokines; (2) interferon-inducible gene expression; and (3) specific receptor interaction on endothelial cells. In this review we will appraise the biology of these angiogenic and angiostatic CXC chemokines, and discuss their disparate angiogenic activity in the context of the pathogenesis of cancer.
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ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2003.10.006