Biological Applications of Protein Splicing

• Published in: Cell Vol. 143; no. 2; pp. 191 - 200
• Main Authors: Vila-Perelló, Miquel, Muir, Tom W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2010
• Subjects: Inteins; Protein Engineering - methods; Protein Processing, Post-Translational; Protein Splicing; Recombinant Proteins - genetics; Recombinant Proteins - metabolism

Protein splicing is a naturally occurring process in which a protein editor, called an intein, performs a molecular disappearing act by cutting itself out of a host protein in a traceless manner. In the two decades since its discovery, protein splicing has been harnessed for the development of sever...