Angiotensin-(1-7) as a biomarker of childhood obesity: Is there a causal relationship?

The renin–angiotensin system (RAS) is a major regulator of cardiovascular and metabolic systems. During the last two decades, angiotensin converting enzyme (ACE) 2-angiotensin- (1–7)-Mas was established as a counteraxis of the classical RAS pathway [1]. Angiotensin-(1–7) functionally antagonizes ang...

Full description

Saved in:
Bibliographic Details
Published inHypertension research Vol. 44; no. 9; pp. 1233 - 1235
Main Authors Nozato, Yoichi, Yamamoto, Koichi
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.09.2021
Springer Singapore
Subjects
Angiotensin I
Biomarkers
Blood pressure
Cardiovascular system
Child
Comment
Endocrine system
Humans
Metabolism
Musculoskeletal system
Obesity
Pediatric Obesity
Pediatrics
Peptide Fragments
Online AccessGet full text

Cover

More Information
Summary:The renin–angiotensin system (RAS) is a major regulator of cardiovascular and metabolic systems. During the last two decades, angiotensin converting enzyme (ACE) 2-angiotensin- (1–7)-Mas was established as a counteraxis of the classical RAS pathway [1]. Angiotensin-(1–7) functionally antagonizes angiotensin II through its receptor, Mas. ACE2, identified as the homolog of ACE, plays a pivotal role in the endogenous production of angiotensin-(1–7) [2]. Substrates of ACE2 are not limited to those within the RAS and involve various peptides, including des-Arg9 -bradykinin (BK). The organprotective role of angiotensin-(1–7) on the cardiovascular, renal, endocrine, and skeletal muscle systems has been well recognized and discussed [1].
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0916-9636
1348-4214
DOI:10.1038/s41440-021-00684-4