Binding of liver lipase to parenchymal and non-parenchymal rat liver cells

The present paper describes the in vitro binding of liver lipase partially purified from postheparin rat serum to isolated liver cells. The binding of liver lipase to non-parenchymal liver cells was 100 times more, per mg cell protein, than to parenchymal cells. The in vitro bound lipase to non-pare...

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Published inBiochemical and biophysical research communications Vol. 85; no. 1; pp. 148 - 152
Main Authors Jansen, H., van Berkel, T.J.C., Hulsmann, W.C.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1978
Subjects
Animals
Kinetics
Lipase - metabolism
Liver - cytology
Liver - metabolism
Male
Rats
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Summary:The present paper describes the in vitro binding of liver lipase partially purified from postheparin rat serum to isolated liver cells. The binding of liver lipase to non-parenchymal liver cells was 100 times more, per mg cell protein, than to parenchymal cells. The in vitro bound lipase to non-parenchymal cells was largely (80%) releasable by heparin. The presented data suggest that in vivo the heparin-releasable liver lipase is mainly (85–92%) located at the surface of non-parenchymal cells.
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SourceType-Scholarly Journals-1
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ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(78)80022-9