The prevalence of anemia in people with chronic kidney disease after hematopoietic stem cell transplantation

• Published in: Renal failure Vol. 45; no. 2; p. 2263581
• Main Authors: Kępska-Dzilińska, Małgorzata, Karakulska-Prystupiuk, Ewa, Kaszyńska, Aleksandra, Basak, Grzegorz W, Małyszko, Jolanta
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 2023; Taylor & Francis; Taylor & Francis Group
• Subjects: Acute lymphoblastic leukemia; Acute myeloid leukemia; Anemia; Anemia - epidemiology; Anemia - etiology; Brief Report; chronic kidney disease; Epidermal growth factor receptors; Female; Hematological diseases; Hematopoietic stem cell transplant; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic stem cells; Hemoglobin; Humans; Kidney diseases; Kidney transplantation; Leukemia; Lymphatic leukemia; Lymphoma; Male; Nephrology; Prevalence; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - therapy; Stem cell transplantation; Womens health; Hematopoietic stem cell transplant; leukemia; chronic kidney disease; anemia; lymphoma
• ISSN: 0886-022X; 1525-6049; 1525-6049
• DOI: 10.1080/0886022X.2023.2263581

The hematopoietic stem cell transplantation (HSCT) is performed for various hematological diseases. Chronic kidney disease (CKD) occurs relatively often after HSCT. Anemia after HSCT may be due to CKD and/or other reasons. The aim of this study is to assess the prevalence of anemia and its possible relationship to the presence of CKD in patients at least 3 months after HSCT. The study included 156 patients who underwent allogeneic HSCT treatment in our center in the years 1998 to 2021 due to different hematologic pathologies (acute myeloid leukemia, acute lymphoblastic leukemia, lymphoma, and others). Anemia was diagnosed in 13% of women and 35% of men. Anemia was most common in people after HSCT due to a history of acute myeloid leukemia (55% women, 30% men). In 56% of women and 17% of men, anemia was associated with chronic kidney disease. In patients with anemia, age was related to the eGFR (r = -0.39,  < 0.001), in patients without anemia age was negatively related to eGFR (r = -0.56,  < 0.001), and hemoglobin was positively related to platelet count (  = 0.62,  < 0.001). Concluding, anemia, was relatively common in CKD after HSCT. In CKD, in particular with coexistent anemia, nephrology referral is to be taken into account to optimize therapy, including nephroprotection.