Mouse models of epithelial ovarian cancer for preclinical studies

Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic...

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Bibliographic Details
Published inDōngwùxué yánjiū Vol. 42; no. 2; pp. 153 - 160
Main Authors Karakashev, Sergey, Zhang, Ru-Gang
Format Journal Article
LanguageEnglish
Published China Kunming Institute of Zoology, The Chinese Academy of Sciences 18.03.2021
Subjects
Animal models
Animals
Antineoplastic Agents - therapeutic use
Ascites
Cancer
Cancer therapies
Disease Models, Animal
Drug Evaluation, Preclinical
FDA approval
Female
Metastasis
Mice
Mortality
Ovarian cancer
Ovarian Neoplasms - drug therapy
Ovaries
Tumors
Patient-derived xenografts
Epithelial ovarian cancer
Syngeneic mouse model
Genetic engineered mouse model
Intraperitoneal mouse model
Orthotopic mouse model
Subcutaneous mouse model
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Summary:Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.
ISSN:2095-8137
0254-5853
DOI:10.24272/J.ISSN.2095-8137.2020.382