Endoscopic diagnosis of cholangiocarcinoma: From endoscopic retrograde cholangiography to bile proteomics

Abstract Cholangiocarcinoma (CCA) is the second most common primary liver cancer. In clinical practice, the diagnosis remains challenging and often requires endoscopic approaches. Endoscopic retrograde and percutaneous transhepatic cholangiography are the first-line endoscopic procedures for the eva...

Full description

Saved in:
Bibliographic Details
Published inBaillière's best practice & research. Clinical gastroenterology Vol. 29; no. 2; pp. 267 - 275
Main Authors Voigtländer, Torsten, M.D, Lankisch, Tim O., M.D
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Limited 01.04.2015
Subjects
Accuracy
Bile
Bile - metabolism
Bile Duct Neoplasms - diagnosis
Bile Ducts, Intrahepatic - pathology
Biopsy
Cellular biology
Cholangiocarcinoma - diagnosis
Cholangiography - methods
Cholangiopancreatography, Endoscopic Retrograde - methods
Confidence intervals
Endoscopy
Flow cytometry
Gastroenterology and Hepatology
Humans
Liver cancer
Medical diagnosis
Medical imaging
Proteomics
Proteomics - methods
Rodents
Ultrasonic imaging
Biliary tract
Endoscopy
Sclerosing cholangitis
Endoscopic retrograde cholangiography
Cholangiocarcinoma
Proteomics
Online AccessGet full text

Cover

More Information
Summary:Abstract Cholangiocarcinoma (CCA) is the second most common primary liver cancer. In clinical practice, the diagnosis remains challenging and often requires endoscopic approaches. Endoscopic retrograde and percutaneous transhepatic cholangiography are the first-line endoscopic procedures for the evaluation of indeterminate bile duct strictures. Tissue acquisition via brush cytology and forceps biopsies allows the cytological and/or histological confirmation of the disease. Due to the low sensitivity of these techniques, repetitive examinations and/or alternative approaches are required. Cholangioscopy, endoscopic and intraductal ultrasound and confocal laser endomicroscopy are additional methods which can be applied for the diagnosis of CCA. Particularly, new experimental approaches like bile and urine proteomic analyses show promising results which have to be evaluated prospectively for further integration in diagnostic algorithms.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1521-6918
1532-1916
DOI:10.1016/j.bpg.2015.02.005