A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor

An iodine-mediated one-pot synthesis of pyrrolo/indolo [1,2-a]quinoxalines and quinazolin-4-one via utilizing epoxides as alkyl precursors under metal-free conditions has been described. Both 1-(2-aminophenyl)-pyrrole and 2-aminobenzamide could be applied to this protocol. A total of 33 desired prod...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 28; no. 21; p. 7391
Main Authors Lv, Xueyan, Lv, Lili, Li, Shichen, Ding, Chengcheng, Yang, Bingchuan, Ma, Chen
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2023
Subjects
Acids
Cancer
Chemical tests and reagents
epoxide
Iodine
Methods
pyrrolo [1,2-a]quinoxalines
quinazolin-4-one
transition-metal free
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Summary:An iodine-mediated one-pot synthesis of pyrrolo/indolo [1,2-a]quinoxalines and quinazolin-4-one via utilizing epoxides as alkyl precursors under metal-free conditions has been described. Both 1-(2-aminophenyl)-pyrrole and 2-aminobenzamide could be applied to this protocol. A total of 33 desired products were obtained with moderate to good yields. This methodology was suitable for wide-scale preparation and the obtained products could be further modified into promising pharmaceutically active reagents.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28217391