Outbreak of acute gastroenteritis in young children with death due to rotavirus genotype G9 in Rio Branco, Brazilian Amazon region, 2005

• Published in: International journal of infectious diseases Vol. 14; no. 10; pp. e898 - e903
• Main Authors: Siqueira, Alessandra A, Santelli, A.C.F.S, Alencar, L.R, Dantas, M.P, Dimech, C.P.N, Carmo, G.M.I, Santos, D.A, Alves, R.M.S, Lucena, M.B.F, Morais, M, Assis, R.M.S, Fialho, A, Mascarenhas, J.D.P, Costa, M, Linhares, A.C, Leite, J.P.G, Araujo, W.N, Hatch, D.L
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.10.2010
• Subjects: Acute Disease; Acute gastroenteritis; Amazon region; Brazil - epidemiology; Case-Control Studies; Child, Preschool; Disease Outbreaks; Gastroenteritis - epidemiology; Gastroenteritis - mortality; Gastroenteritis - virology; Genotype; Humans; Infant; Infectious Disease; Outbreak; Pulmonary/Respiratory; Risk Factors; Rotavirus; Rotavirus - genetics; Rotavirus - isolation & purification; Rotavirus Infections - epidemiology; Rotavirus Infections - mortality; Rotavirus Infections - virology; Brazil; Outbreak; Rotavirus; Amazon region; Acute gastroenteritis
• ISSN: 1201-9712; 1878-3511
• DOI: 10.1016/j.ijid.2010.03.024

Summary Background An epidemic of acute gastroenteritis occurred in Rio Branco City, Acre State, in Brazil's Amazon region in 2005. An investigation was conducted to confirm the etiology and identify possible risk factors for death. Methods Rio Branco municipality surveillance data for the period May to October 2005 were reviewed. In a case–control study, children who died following acute gastroenteritis were compared to age-matched controls with acute gastroenteritis who survived. Rotavirus A (RV-A) was investigated in 799 stool samples and genotyped by reverse transcription polymerase chain reaction (RT-PCR). Results The cumulative incidence of diarrhea in children aged <5 years was 21%. A fatal outcome was significantly associated with uncovered household water storage containers. RV-A was identified in 88% of samples and G9 was the prevalent genotype (71%). Conclusions Oral rehydration solution and boiling or chlorinating drinking water likely limited mortality. This epidemic was caused by RV-A genotype G9. After the outbreak, a rotavirus vaccine was introduced into the official childhood immunization schedule in Brazil.