Association of serum pancreatic derived factor (PANDER) with beta-cell dysfunction in type 2 diabetes mellitus

• Published in: Journal of diabetes and its complications Vol. 31; no. 4; pp. 748 - 752
• Main Authors: Shehata, Miral M., Kamal, Mohamed M., El-Hefnawy, Mohamed H., EL-Mesallamy, Hala O.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2017; Elsevier Limited
• Subjects: Algorithms; Beta-cell dysfunction; Biomarkers - blood; Body mass index; C-Peptide - blood; Cholesterol; Cytokines; Cytokines - blood; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Disease Progression; Egypt; Endocrinology; Endocrinology & Metabolism; Enzyme-Linked Immunosorbent Assay; Female; Glucose; HOMA-2%β; Homeostasis; Hospitals, Special; Humans; Insulin - blood; Insulin - metabolism; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells - metabolism; Islet-secreted cytokine; Linear Models; Male; Metabolism; Middle Aged; Neoplasm Proteins - blood; Outpatient Clinics, Hospital; PANDER; Peptides; Proinsulin - blood; Rodents; Type 2 diabetes mellitus; Up-Regulation; Egypt; United States > US; Cairo Egypt; PANDER; Islet-secreted cytokine; HOMA-2%β; Beta-cell dysfunction; Type 2 diabetes mellitus
• ISSN: 1056-8727; 1873-460X; 1873-460X
• DOI: 10.1016/j.jdiacomp.2017.01.001

Beta-cell dysfunction is the critical determinant for type 2 diabetes. The novel PANcreatic DERived factor (PANDER) has been identified as interesting islet-secreted cytokine that might be involved in beta-cell dysfunction, a role that has n”ot been clinically elucidated yet. Therefore, this study was designed to study the potential clinical association of this cytokine with beta-cell dysfunction in type 2 diabetes. Anthropometric parameters, routine biochemical markers and serum levels of PANDER were measured in 63 diabetic subjects including; recently diagnosed type 2 diabetic patients with duration of diabetes ≤6months and long-standing type 2 diabetic patients with duration of diabetes ≥5years then compared to 16 healthy control volunteers. Proinsulin, C-peptide, insulin and PANDER were measured by ELISA. Beta-cell dysfunction was assessed by HOMA2-%β, proinsulin, proinsulin-to-insulin (PI/I) ratio and proinsulin-to-C-peptide (PI/C-pep) ratio. Relations among various parameters were studied using simple and multiple linear regressions. Serum PANDER levels were found to be significantly elevated in long-standing diabetics as compared to recently diagnosed diabetics and controls. In addition, PANDER was found to be significantly correlated negatively to HOMA2-%β, as well as positively to proinsulin, PI/I and PI/C-pep ratios. PANDER is associated with beta-cell dysfunction in diabetic patients.