Protective effects of curcumin and beta-carotene on cisplatin-induced cardiotoxicity: An experimental rat model

• Published in: Anatolian journal of cardiology Vol. 19; no. 3; pp. 213 - 221
• Main Authors: Bahadır, Anzel, Ceyhan, Ayşe, Öz Gergin, Özlem, Yalçın, Betül, Ülger, Menekşe, Özyazgan, Tuğçe Merve, Yay, Arzu
• Format: Journal Article
• Language: English
• Published: Turkey Kare Publishing 01.03.2018
• Subjects: Chemotherapy; Cytokines; Original Investigation; Rodents; Tumor necrosis factor-TNF
• ISSN: 2149-2263; 2149-2271
• DOI: 10.14744/AnatolJCardiol.2018.53059

Cisplatin (CDDP) has been known to be an effective antineoplastic drug; however, it has a cardiotoxic effect. Curcumin (CMN) and beta-carotene (BC) have been suggested to protect biological systems against CDDP-induced damage. The current study was conducted to evaluate the possible protective roles of CMN and BC on CDDP-induced cardiotoxicity in rat cardiac tissues. A total of 49 adult female Wistar albino rats were equally divided into seven groups as follows: control (no medication), sesame oil (1 mg/kg), CDDP (single dose injection two times as once a week, 5 mg/kg/week), BC (100 mg/kg), CDDP+BC (pretreated BC for 30 min before CDDP injection), CMN (200 mg/kg), and CDDP+CMN (pretreated CMN for 30 min before CDDP injection). These treatments were applied intraperitoneally for CDDP and with gavage for CMN and BC. The oxidative/antioxidant indicators, inflammatory cytokines, and histopathological alterations were examined. These alterations included a marked increase in malondialdehyde (MDA) level, significant decrease in catalase (CAT) and superoxide dismutase (SOD) activities, and significant elevation of tumor necrosis factor (TNF)-α, interleukin (IL)-1ß, interleukin (IL)-6 in the CDDP group compared with the other groups. Histopathologically, CDDP-induced severe myocardial degenerative changes were observed. However, the CDDP-induced disturbances in the above-mentioned parameters significantly improved by treatment with BC and particularly CMN. This study indicated that CDDP treatment markedly caused cardiotoxicity; however, treatment with CMN or BC ameliorated this cardiotoxicity in rats. Furthermore, these findings revealed that treatment with CMN has a higher cardioprotective effect than that with BC against CDDP-induced cardiotoxicity in rat cardiac tissues.