measurement of ethylenethiourea and ethyleneurea in the rat and common marmoset Callithrix jacchus after zineb (zinc ethylenebisdithiocarbamate) dosing

The metabolism of the fungicide zineb, (zinc ethylenebisdithiocarbamate), has been studied in the rat and the marmoset. 2. It was found in both species that a relatively large proportion (21-22%) of the original zineb administered was detectable in the excreta as ethylenethiourea (ETU) a known mutag...

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Bibliographic Details
Published inXenobiotica Vol. 17; no. 6; pp. 733 - 740
Main Authors Searle, A.J.F, Stewart, A.C, Paul, M
Format Journal Article
LanguageEnglish
Published England 1987
Subjects
Animals
Biotransformation
Callitrichidae
Callitrichinae - metabolism
Ethylenethiourea - metabolism
Imidazoles - metabolism
Imidazolidines
metabolism
mutagenicity
Photochemistry
Rats
Species Specificity
Thiocarbamates - metabolism
toxicity
urea
zineb
Zineb - metabolism
Zineb - toxicity
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Summary:The metabolism of the fungicide zineb, (zinc ethylenebisdithiocarbamate), has been studied in the rat and the marmoset. 2. It was found in both species that a relatively large proportion (21-22%) of the original zineb administered was detectable in the excreta as ethylenethiourea (ETU) a known mutagen, teratogen and carcinogen. 3. A further proportion (2-5%) was determined to be ethyleneurea which is a metabolite of ETU. 4. Results of comparative experiments in marmosets revealed that ETU was photolabile in the presence of excreta, thus showing the importance of conducting the studies in the dark.
ISSN:0049-8254
1366-5928
DOI:10.3109/00498258709043980