Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein

Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on the scavenging abilities and mechanism of ferulic acid and some other phenolic acids against acrolein. Among the 13 phenolic compounds investi...

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Published in	Journal of Zhejiang University. B. Science Vol. 20; no. 11; pp. 868 - 876
Main Authors	Tao, Zhi-hao, Li, Chang, Xu, Xiao-fei, Pan, Yuan-jiang
Format	Journal Article
Language	English
Published	Hangzhou Zhejiang University Press 01.11.2019 Springer Nature B.V
Subjects	Acids Acrolein Acrolein - chemistry Acrolein - toxicity Biomedical and Life Sciences Biomedicine Carbonyl compounds Carbonyls Coumaric Acids - chemistry Coumaric Acids - pharmacology Ferulic acid Gas chromatography Glutathione - physiology Hydroxybenzoates - pharmacology Magnetic Resonance Spectroscopy Mass spectrometry Mass spectroscopy NMR Nuclear magnetic resonance Phenolic acids Phenols Physiology Scavenging Structure-Activity Relationship Reactive carbonyl species Acrolein Oxidative stress O69 氧化应激反应丙烯醛 Cytotoxicity 细胞毒性活性羰基化合物 Ferulic acid 阿魏酸 Acrolein; Reactive carbonyl species; Ferulic acid; Cytotoxicity; Oxidative stress
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Abstract	Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on the scavenging abilities and mechanism of ferulic acid and some other phenolic acids against acrolein. Among the 13 phenolic compounds investigated, ferulic acid was found to have the highest efficiency in scavenging acrolein under physiological conditions. Ferulic acid remained at (3.04±1.89)% and acrolein remained at (29.51±4.44)% after being incubated with each other for 24 h. The molecular mechanism of the detoxifying process was also studied. Detoxifying products, namely 2-methoxy-4-vinylphenol (product 21 ) and 5-(4-hydroxy-3-methoxyphenyl)pent-4-enal (product 22 ), were identified though nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS), after the scavenging process. Ferulic acid showed significant activity in scavenging acrolein under physiological conditions. This study indicates a new method for inhibiting damage from acrolein.
AbstractList	Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on the scavenging abilities and mechanism of ferulic acid and some other phenolic acids against acrolein. Among the 13 phenolic compounds investigated, ferulic acid was found to have the highest efficiency in scavenging acrolein under physiological conditions. Ferulic acid remained at (3.04±1.89)% and acrolein remained at (29.51±4.44)% after being incubated with each other for 24 h. The molecular mechanism of the detoxifying process was also studied. Detoxifying products, namely 2-methoxy-4-vinylphenol (product 21 ) and 5-(4-hydroxy-3-methoxyphenyl)pent-4-enal (product 22 ), were identified though nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS), after the scavenging process. Ferulic acid showed significant activity in scavenging acrolein under physiological conditions. This study indicates a new method for inhibiting damage from acrolein. Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on the scavenging abilities and mechanism of ferulic acid and some other phenolic acids against acrolein. Among the 13 phenolic compounds investigated, ferulic acid was found to have the highest efficiency in scavenging acrolein under physiological conditions. Ferulic acid remained at (3.04±1.89)% and acrolein remained at (29.51±4.44)% after being incubated with each other for 24 h. The molecular mechanism of the detoxifying process was also studied. Detoxifying products, namely 2-methoxy-4-vinylphenol (product 21) and 5-(4-hydroxy-3-methoxyphenyl)pent-4-enal (product 22), were identified though nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS), after the scavenging process. Ferulic acid showed significant activity in scavenging acrolein under physiological conditions. This study indicates a new method for inhibiting damage from acrolein.
Author	Xu, Xiao-fei Pan, Yuan-jiang Li, Chang Tao, Zhi-hao
AuthorAffiliation	1 Department of Chemistry, Zhejiang University, Hangzhou 310027, China 2 College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China
AuthorAffiliation_xml	– name: 2 College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China – name: 1 Department of Chemistry, Zhejiang University, Hangzhou 310027, China
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Keywords	Reactive carbonyl species Acrolein Oxidative stress O69 氧化应激反应丙烯醛 Cytotoxicity 细胞毒性活性羰基化合物 Ferulic acid 阿魏酸 Acrolein; Reactive carbonyl species; Ferulic acid; Cytotoxicity; Oxidative stress
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Snippet	Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on...
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SubjectTerms	Acids Acrolein Acrolein - chemistry Acrolein - toxicity Biomedical and Life Sciences Biomedicine Carbonyl compounds Carbonyls Coumaric Acids - chemistry Coumaric Acids - pharmacology Ferulic acid Gas chromatography Glutathione - physiology Hydroxybenzoates - pharmacology Magnetic Resonance Spectroscopy Mass spectrometry Mass spectroscopy NMR Nuclear magnetic resonance Phenolic acids Phenols Physiology Scavenging Structure-Activity Relationship
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Title	Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein
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