Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein

• Published in: Journal of Zhejiang University. B. Science Vol. 20; no. 11; pp. 868 - 876
• Main Authors: Tao, Zhi-hao, Li, Chang, Xu, Xiao-fei, Pan, Yuan-jiang
• Format: Journal Article
• Language: English
• Published: Hangzhou Zhejiang University Press 01.11.2019; Springer Nature B.V
• Subjects: Acids; Acrolein; Acrolein - chemistry; Acrolein - toxicity; Biomedical and Life Sciences; Biomedicine; Carbonyl compounds; Carbonyls; Coumaric Acids - chemistry; Coumaric Acids - pharmacology; Ferulic acid; Gas chromatography; Glutathione - physiology; Hydroxybenzoates - pharmacology; Magnetic Resonance Spectroscopy; Mass spectrometry; Mass spectroscopy; NMR; Nuclear magnetic resonance; Phenolic acids; Phenols; Physiology; Scavenging; Structure-Activity Relationship; Reactive carbonyl species; Acrolein; Oxidative stress; O69; 氧化应激反应; 丙烯醛; Cytotoxicity; 细胞毒性; 活性羰基化合物; Ferulic acid; 阿魏酸; Acrolein; Reactive carbonyl species; Ferulic acid; Cytotoxicity; Oxidative stress
• ISSN: 1673-1581; 1862-1783
• DOI: 10.1631/jzus.B1900211

Acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on the scavenging abilities and mechanism of ferulic acid and some other phenolic acids against acrolein. Among the 13 phenolic compounds investigated, ferulic acid was found to have the highest efficiency in scavenging acrolein under physiological conditions. Ferulic acid remained at (3.04±1.89)% and acrolein remained at (29.51±4.44)% after being incubated with each other for 24 h. The molecular mechanism of the detoxifying process was also studied. Detoxifying products, namely 2-methoxy-4-vinylphenol (product 21 ) and 5-(4-hydroxy-3-methoxyphenyl)pent-4-enal (product 22 ), were identified though nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS), after the scavenging process. Ferulic acid showed significant activity in scavenging acrolein under physiological conditions. This study indicates a new method for inhibiting damage from acrolein.