Surfactant Protein Genetic Marker Alleles Identify a Subgroup of Tuberculosis in a Mexican Population

• Published in: The Journal of infectious diseases Vol. 182; no. 5; pp. 1473 - 1478
• Main Authors: Floros, Joanna, Lin, Hung-Mo, García, Andrea, Salazar, Miguel Angel, Guo, Xiaoxuan, DiAngelo, Susan, Montaño, Martha, Luo, Junming, Pardo, Annie, Selman, Moises
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.11.2000; University of Chicago Press; Oxford University Press
• Subjects: Adult; Aged; Alleles; Alveolar macrophages; Amino acids; Bacteriology; Biological and medical sciences; Control groups; Cutaneous tuberculosis; Female; Fundamental and applied biological sciences. Psychology; Genetic Markers; Glycoproteins - genetics; Humans; Logistic regression; Major Articles; Male; Mexico; Microbiology; Middle Aged; Mycobacterium tuberculosis; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; Polymerase chain reaction; Proteolipids - genetics; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein D; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants - genetics; surfactant protein A; surfactant protein D; Surfactants; Tuberculin Test; Tuberculosis; Tuberculosis - etiology; Tuberculosis - genetics; Central America; Mexico; America; Human; Genetic marker; Respiratory disease; Host agent relation; Mycobacterial infection; Genetic determinism; Infection; Allele; Microorganism resistance; Tuberculosis; Mycobacterium tuberculosis; Pulmonary surfactant; Mycobacteriales; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/315866

Pulmonary surfactant and its components are essential for normal lung function and are involved in local host defense. Surfactant protein (SP)—A and SP-D bind to and modulate phagocytosis of Mycobacterium tuberculosis by macrophages. Frequency comparisons of SP marker alleles in tuberculosis patients and healthy control subjects (tuberculin—skin test positive or general population) were performed. Regression analyses of the tuberculosis and the tuberculin—skin test positive groups revealed, on the basis of odds ratios, tuberculosis susceptibility (DA11_C and GATA_3) and protective (AAGG_2) marker alleles. Similarly, between tuberculosis patients and general population control subjects, susceptibility 1A3, 6A4, and B1013_A and protective AA GG_1, and AA GG_7 marker alleles were observed. Moreover, interactions were seen between alleles 6A2 and 1A3 (P = .0064) and between 1A3 and B1013_A (P = .036). The findings indicate a possible involvement of SP alleles in tuberculosis pathogenesis.