Methamphetamine mortality to emotional stimuli administered in the form of affective communication

Methamphetamine induced mortality in physically stressed and non-physically stressed mice was investigated by employing a communication box in which shocked mice communicated their distress to unshocked mice in neighboring boxes. Intraperitoneal administration of methamphetamine 30 mg/kg caused grea...

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Bibliographic Details
Published inLife sciences (1973) Vol. 32; no. 9; p. 941
Main Authors Gomita, Y, Kataoka, Y, Ichimaru, Y, Ueki, S
Format Journal Article
LanguageEnglish
Published Netherlands 28.02.1983
Subjects
Animal Communication
Animals
Electroshock
Emotions
Humans
Male
Methamphetamine - toxicity
Mice
Social Behavior
Social Isolation
Stress, Physiological - mortality
Stress, Psychological - mortality
Temperature
Time Factors
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Summary:Methamphetamine induced mortality in physically stressed and non-physically stressed mice was investigated by employing a communication box in which shocked mice communicated their distress to unshocked mice in neighboring boxes. Intraperitoneal administration of methamphetamine 30 mg/kg caused greater mortality in both the shocked "sender" mice and the unshocked "responder" mice than in control when maintained at 27 +/- 1 degree C. Forty-eight hours after injection, the "sender", "responder" and control mice showed mortality of 80, 60 and 10%, respectively. This result indicates that the mortality of methamphetamine may be potentiated not only by physical stress but also by non-physical stress.
ISSN:0024-3205
DOI:10.1016/0024-3205(83)90923-2