Translational research: A patient-centered approach to bridge the valley of death
Animal models have evolved to be a key component of translational research of cancer, and they are now extensively used to test drug candidates, predict drug responses, and essentially drive discovery of cancer biology. However, the model-centric approach has not yielded the expected abundance of tr...
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| Published in | Cancer Cell Vol. 40; no. 6; pp. 565 - 568 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
13.06.2022
Elsevier BV |
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| Abstract | Animal models have evolved to be a key component of translational research of cancer, and they are now extensively used to test drug candidates, predict drug responses, and essentially drive discovery of cancer biology. However, the model-centric approach has not yielded the expected abundance of treatment advances. We propose that the focus of translational research needs to shift from animal models to human patients, and the goal should be to understand why tumor responses and outcomes are so variable between patients and how it can be predicted at the individual level and thus to generate hypotheses that are more relevant to people than to atypically sensitive animal models. |
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| AbstractList | Animal models have evolved to be a key component of translational research of cancer, and they are now extensively used to test drug candidates, predict drug responses, and essentially drive discovery of cancer biology. However, the model-centric approach has not yielded the expected abundance of treatment advances. We propose that the focus of translational research needs to shift from animal models to human patients, and the goal should be to understand why tumor responses and outcomes are so variable between patients and how it can be predicted at the individual level and thus to generate hypotheses that are more relevant to people than to atypically sensitive animal models.Animal models have evolved to be a key component of translational research of cancer, and they are now extensively used to test drug candidates, predict drug responses, and essentially drive discovery of cancer biology. However, the model-centric approach has not yielded the expected abundance of treatment advances. We propose that the focus of translational research needs to shift from animal models to human patients, and the goal should be to understand why tumor responses and outcomes are so variable between patients and how it can be predicted at the individual level and thus to generate hypotheses that are more relevant to people than to atypically sensitive animal models. Animal models have evolved to be a key component of translational research of cancer, and they are now extensively used to test drug candidates, predict drug responses, and essentially drive discovery of cancer biology. However, the model-centric approach has not yielded the expected abundance of treatment advances. We propose that the focus of translational research needs to shift from animal models to human patients, and the goal should be to understand why tumor responses and outcomes are so variable between patients and how it can be predicted at the individual level and thus to generate hypotheses that are more relevant to people than to atypically sensitive animal models. |
| Author | Desai, Parth Thomas, Anish Takahashi, Nobuyuki |
| Author_xml | – sequence: 1 givenname: Anish surname: Thomas fullname: Thomas, Anish email: anish.thomas@nih.gov organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA – sequence: 2 givenname: Parth surname: Desai fullname: Desai, Parth organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA – sequence: 3 givenname: Nobuyuki surname: Takahashi fullname: Takahashi, Nobuyuki organization: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA |
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| Cites_doi | 10.1073/pnas.1222878110 10.1016/j.ccell.2020.10.015 10.1158/1078-0432.CCR-19-3841 10.1016/j.cell.2021.11.017 10.1056/NEJMoa1916623 10.1038/ng.3967 10.1038/453840a 10.1038/sj.embor.7400422 10.1038/s41568-018-0095-3 10.1001/jama.2017.3438 10.1038/nature10937 10.1158/1078-0432.CCR-21-2275 10.1038/s41467-022-29517-9 10.1056/NEJMoa040938 |
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| Title | Translational research: A patient-centered approach to bridge the valley of death |
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