Translational research: A patient-centered approach to bridge the valley of death

Animal models have evolved to be a key component of translational research of cancer, and they are now extensively used to test drug candidates, predict drug responses, and essentially drive discovery of cancer biology. However, the model-centric approach has not yielded the expected abundance of tr...

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Bibliographic Details
Published inCancer Cell Vol. 40; no. 6; pp. 565 - 568
Main Authors Thomas, Anish, Desai, Parth, Takahashi, Nobuyuki
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.06.2022
Elsevier BV
Subjects
Animals
Humans
Patient-Centered Care
Translational Research, Biomedical
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Summary:Animal models have evolved to be a key component of translational research of cancer, and they are now extensively used to test drug candidates, predict drug responses, and essentially drive discovery of cancer biology. However, the model-centric approach has not yielded the expected abundance of treatment advances. We propose that the focus of translational research needs to shift from animal models to human patients, and the goal should be to understand why tumor responses and outcomes are so variable between patients and how it can be predicted at the individual level and thus to generate hypotheses that are more relevant to people than to atypically sensitive animal models.
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ISSN:1535-6108
1878-3686
1878-3686
DOI:10.1016/j.ccell.2022.04.014