novel antibiotic produced by streptomyces noursei Da07210
A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzo[d]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related c...
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Published in | Antonie van Leeuwenhoek Vol. 96; no. 1; pp. 109 - 112 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Dordrecht : Springer Netherlands
01.06.2009
Springer Netherlands Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzo[d]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related cycloheximide. Experiments demonstrated that 210-A bore strong activity against Fusarium oxysporum f. sp. cubense race four (Foc race four), which also showed antitumor activity against SMMC-7721 human hepatocarcinoma cells and S180 murine sarcoma, and the IC₅₀ values were 0.77 and 0.74 μg/ml, respectively. |
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Bibliography: | http://dx.doi.org/10.1007/s10482-009-9333-8 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0003-6072 1572-9699 |
DOI: | 10.1007/s10482-009-9333-8 |