novel antibiotic produced by streptomyces noursei Da07210

• Published in: Antonie van Leeuwenhoek Vol. 96; no. 1; pp. 109 - 112
• Main Authors: Wu, Xiaopeng, Huang, Huiqin, Chen, Guangying, Sun, Qianguang, Peng, Jie, Zhu, Jun, Bao, Shixiang
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.06.2009; Springer Netherlands; Springer; Springer Nature B.V
• Subjects: Animals; Antibiotics; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - isolation & purification; Antibiotics, Antineoplastic - pharmacology; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Applied microbiology; Bacteria; Biological and medical sciences; Biomedical and Life Sciences; Bridged Bicyclo Compounds, Heterocyclic - chemistry; Bridged Bicyclo Compounds, Heterocyclic - isolation & purification; Bridged Bicyclo Compounds, Heterocyclic - pharmacology; Cell Line, Tumor; Fermentation; Fundamental and applied biological sciences. Psychology; Fusarium - drug effects; Fusarium oxysporum; Humans; Inhibitory Concentration 50; Life Sciences; Medical Microbiology; Medical sciences; Mice; Microbial Sensitivity Tests; Microbiology; Miscellaneous. Antibiotics with multiple activities; Pesticides; Pharmacology. Drug treatments; Plant Sciences; Sarcoma; Short Communication; Soil Science & Conservation; Spectrum Analysis; Streptomyces - chemistry; Streptomyces noursei; Studies; Antifungal activity; Antitumor activity; Actinomycete; Fungicide; Antineoplastic agent; Streptomycetaceae; Pesticides; In vitro; Biological activity; Actinomycetales; Antibiotic; Antifungal agent; Bacteria; Actinomycetes; Streptomyces noursei
• ISSN: 0003-6072; 1572-9699
• DOI: 10.1007/s10482-009-9333-8

A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzo[d]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related cycloheximide. Experiments demonstrated that 210-A bore strong activity against Fusarium oxysporum f. sp. cubense race four (Foc race four), which also showed antitumor activity against SMMC-7721 human hepatocarcinoma cells and S180 murine sarcoma, and the IC₅₀ values were 0.77 and 0.74 μg/ml, respectively.